{
 "name": "Oliver Hahn",
 "papers": [
  {
   "title": "Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging",
   "venue": "bioRxiv (preprint)",
   "year": 2025,
   "doi": "10.1101/2025.09.02.673859",
   "url": "https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1",
   "summary": "Young replacement microglia, the brain's immune cells, aged fast in old brains. Old ones looked young in young brains.",
   "selected": true,
   "role": "senior author and lead contact",
   "commentary": [
    {
     "source": "Alzforum",
     "title": "Regional Cues and Natural Killer Cells Steer Microglial Aging",
     "url": "https://www.alzforum.org/news/research-news/regional-cues-and-natural-killer-cells-steer-microglial-aging"
    },
    {
     "source": "Lifespan.io",
     "title": "Microglial Aging Is Determined by Their Environment",
     "url": "https://lifespan.io/news/microglial-aging-is-determined-by-their-environment/"
    }
   ],
   "data_url": "https://tinyurl.com/Microglial-Aging-Explorer"
  },
  {
   "title": "A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase",
   "venue": "Nature Communications",
   "year": 2025,
   "doi": "10.1038/s41467-025-59860-6",
   "url": "https://www.nature.com/articles/s41467-025-59860-6",
   "summary": "A microRNA atlas of 15 mouse brain regions. miR-155-5p rises with age in both sexes, driven by microglia.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis",
   "venue": "Nature Neuroscience",
   "year": 2024,
   "doi": "10.1038/s41593-024-01609-3",
   "url": "https://www.nature.com/articles/s41593-024-01609-3",
   "summary": "Replacing immune cells by transplant improved neurological deficits in a mouse model of multiple sclerosis.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Atlas of the aging mouse brain reveals white matter as vulnerable foci",
   "venue": "Cell",
   "year": 2023,
   "doi": "10.1016/j.cell.2023.07.027",
   "url": "https://www.cell.com/cell/fulltext/S0092-8674(23)00805-X",
   "summary": "We profiled 15 mouse brain regions across 7 ages. Glial aging runs faster in white matter than cortex.",
   "selected": true,
   "role": "first author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues",
   "venue": "Nature Biotechnology",
   "year": 2023,
   "doi": "10.1038/s41587-023-01751-6",
   "url": "https://www.nature.com/articles/s41587-023-01751-6",
   "summary": "A noncoding RNA map of 16 organs. miR-29c-3p tracks aging and returns to young levels in liver with young blood.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Ageing-associated changes in transcriptional elongation influence longevity",
   "venue": "Nature",
   "year": 2023,
   "doi": "10.1038/s41586-023-05922-y",
   "url": "https://www.nature.com/articles/s41586-023-05922-y",
   "summary": "RNA polymerase speeds up with age in five species. Dietary restriction reverses most of this, and slowing polymerase extends lifespan.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice",
   "venue": "Nature Aging",
   "year": 2023,
   "doi": "10.1038/s43587-023-00468-0",
   "url": "https://www.nature.com/articles/s43587-023-00468-0",
   "summary": "Klotho raises platelet factors in blood. One of them, PF4, improves cognition in young and old mice.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17",
   "venue": "Nature",
   "year": 2022,
   "doi": "10.1038/s41586-022-04722-0",
   "url": "https://www.nature.com/articles/s41586-022-04722-0",
   "summary": "Young cerebrospinal fluid improved memory in old mice. Fgf17 alone did too.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Exercise plasma boosts memory and dampens brain inflammation via clusterin",
   "venue": "Nature",
   "year": 2021,
   "doi": "10.1038/s41586-021-04183-x",
   "url": "https://www.nature.com/articles/s41586-021-04183-x",
   "summary": "Plasma from running mice reduced brain inflammation in sedentary mice, through proteins including clusterin.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Dysregulation of brain and choroid plexus cell types in severe COVID-19",
   "venue": "Nature",
   "year": 2021,
   "doi": "10.1038/s41586-021-03710-0",
   "url": "https://www.nature.com/articles/s41586-021-03710-0",
   "summary": "Brains from COVID-19 patients showed no molecular trace of virus but broad changes in barrier cells and microglia.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method",
   "venue": "Nucleic Acids Research",
   "year": 2020,
   "doi": "10.1093/nar/gkaa1127",
   "url": "https://doi.org/10.1093/nar/gkaa1127",
   "summary": "CoolMPS sequencing reproduced standard Illumina results on single-nucleus RNA from young and old mouse hippocampus.",
   "selected": true,
   "role": "first author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Ageing hallmarks exhibit organ-specific temporal signatures",
   "venue": "Nature",
   "year": 2020,
   "doi": "10.1038/s41586-020-2499-y",
   "url": "https://www.nature.com/articles/s41586-020-2499-y",
   "summary": "Organs hit the same aging hallmarks on different schedules. Immune activation shows first in white fat.",
   "selected": true,
   "role": "co-first author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain",
   "venue": "Nature Neuroscience",
   "year": 2020,
   "doi": "10.1038/s41593-019-0566-1",
   "url": "https://www.nature.com/articles/s41593-019-0566-1",
   "summary": "Microglia fill with lipid droplets as brains age. These cells clear debris poorly and drive inflammation.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "A single-cell transcriptomic atlas characterizes ageing tissues in the mouse",
   "venue": "Nature",
   "year": 2020,
   "doi": "10.1038/s41586-020-2496-1",
   "url": "https://www.nature.com/articles/s41586-020-2496-1",
   "summary": "A single-cell atlas of aging across 23 mouse tissues and organs.",
   "selected": false,
   "role": "consortium member",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "A nutritional memory effect counteracts the benefits of dietary restriction in old mice",
   "venue": "Nature Metabolism",
   "year": 2019,
   "doi": "10.1038/s42255-019-0121-0",
   "url": "https://www.nature.com/articles/s42255-019-0121-0",
   "summary": "In 800 mice, stopping dietary restriction at 24 months raised mortality fast. Starting it late helped only weakly.",
   "selected": true,
   "role": "first author",
   "commentary": [
    {
     "source": "Nature Metabolism News & Views",
     "title": "The diet and the damage done",
     "url": "https://www.nature.com/articles/s42255-019-0128-6"
    }
   ],
   "data_url": ""
  },
  {
   "title": "Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity",
   "venue": "PLOS Genetics",
   "year": 2018,
   "doi": "10.1371/journal.pgen.1007766",
   "url": "https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007766",
   "summary": "Dietary restriction, rapamycin and dwarf genetics each add methylation inside gene bodies in mouse liver.",
   "selected": true,
   "role": "first author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism",
   "venue": "Genome Biology",
   "year": 2017,
   "doi": "10.1186/s13059-017-1187-1",
   "url": "https://link.springer.com/article/10.1186/s13059-017-1187-1",
   "summary": "Dietary restriction delayed age-related epigenetic changes in mouse liver and added methylation at lipid genes.",
   "selected": true,
   "role": "co-first author",
   "commentary": [
    {
     "source": "Genome Biology Research Highlight",
     "title": "Epigenetic aging clocks in mice and men",
     "url": "https://link.springer.com/article/10.1186/s13059-017-1245-8"
    }
   ],
   "data_url": ""
  },
  {
   "title": "The Sense of Smell Impacts Metabolic Health and Obesity",
   "venue": "Cell Metabolism",
   "year": 2017,
   "doi": "10.1016/j.cmet.2017.06.015",
   "url": "https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30357-1",
   "summary": "Mice that lost smell neurons resisted diet-induced obesity. Losing smell after obesity reduced fat mass.",
   "selected": false,
   "role": "contributing author",
   "commentary": [],
   "data_url": ""
  },
  {
   "title": "Inferring causal molecular networks: empirical assessment through a community-based effort",
   "venue": "Nature Methods",
   "year": 2016,
   "doi": "10.1038/nmeth.3773",
   "url": "https://www.nature.com/articles/nmeth.3773",
   "summary": "A community challenge scored over 2,000 networks for causal links in cancer cell signaling.",
   "selected": false,
   "role": "consortium member",
   "commentary": [],
   "data_url": ""
  }
 ]
}