[
 {
  "id": "2025-microglia-environment",
  "title": "Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging",
  "year": 2025,
  "venue": "bioRxiv (preprint)",
  "doi": "10.1101/2025.09.02.673859",
  "url": "https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1",
  "summary": "Young replacement microglia, the brain's immune cells, aged fast in old brains. Old ones looked young in young brains."
 },
 {
  "id": "hahn-2023-brain-atlas",
  "title": "Atlas of the aging mouse brain reveals white matter as vulnerable foci",
  "year": 2023,
  "venue": "Cell",
  "doi": "10.1016/j.cell.2023.07.027",
  "url": "https://www.cell.com/cell/fulltext/S0092-8674(23)00805-X",
  "summary": "We profiled 15 mouse brain regions across 7 ages. Glial aging runs faster in white matter than cortex."
 },
 {
  "id": "hahn-2020-coolmps",
  "title": "CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method",
  "year": 2020,
  "venue": "Nucleic Acids Research",
  "doi": "10.1093/nar/gkaa1127",
  "url": "https://doi.org/10.1093/nar/gkaa1127",
  "summary": "CoolMPS sequencing reproduced standard Illumina results on single-nucleus RNA from young and old mouse hippocampus."
 },
 {
  "id": "schaum-2020-organ-aging",
  "title": "Ageing hallmarks exhibit organ-specific temporal signatures",
  "year": 2020,
  "venue": "Nature",
  "doi": "10.1038/s41586-020-2499-y",
  "url": "https://www.nature.com/articles/s41586-020-2499-y",
  "summary": "Organs hit the same aging hallmarks on different schedules. Immune activation shows first in white fat."
 },
 {
  "id": "hahn-2019-nutritional-memory",
  "title": "A nutritional memory effect counteracts the benefits of dietary restriction in old mice",
  "year": 2019,
  "venue": "Nature Metabolism",
  "doi": "10.1038/s42255-019-0121-0",
  "url": "https://www.nature.com/articles/s42255-019-0121-0",
  "summary": "In 800 mice, stopping dietary restriction at 24 months raised mortality fast. Starting it late helped only weakly."
 },
 {
  "id": "hahn-2018-gene-body-methylation",
  "title": "Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity",
  "year": 2018,
  "venue": "PLOS Genetics",
  "doi": "10.1371/journal.pgen.1007766",
  "url": "https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007766",
  "summary": "Dietary restriction, rapamycin and dwarf genetics each add methylation inside gene bodies in mouse liver."
 },
 {
  "id": "hahn-2017-dr-methylation",
  "title": "Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism",
  "year": 2017,
  "venue": "Genome Biology",
  "doi": "10.1186/s13059-017-1187-1",
  "url": "https://link.springer.com/article/10.1186/s13059-017-1187-1",
  "summary": "Dietary restriction delayed age-related epigenetic changes in mouse liver and added methylation at lipid genes."
 },
 {
  "id": "engel-2025-mirna-atlas",
  "title": "A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase",
  "year": 2025,
  "venue": "Nature Communications",
  "doi": "10.1038/s41467-025-59860-6",
  "url": "https://www.nature.com/articles/s41467-025-59860-6",
  "summary": "A microRNA atlas of 15 mouse brain regions. miR-155-5p rises with age in both sexes, driven by microglia."
 },
 {
  "id": "mader-2024-myeloid-replacement",
  "title": "Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis",
  "year": 2024,
  "venue": "Nature Neuroscience",
  "doi": "10.1038/s41593-024-01609-3",
  "url": "https://www.nature.com/articles/s41593-024-01609-3",
  "summary": "Replacing immune cells by transplant improved neurological deficits in a mouse model of multiple sclerosis."
 },
 {
  "id": "wagner-2023-noncoding-rna",
  "title": "Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues",
  "year": 2023,
  "venue": "Nature Biotechnology",
  "doi": "10.1038/s41587-023-01751-6",
  "url": "https://www.nature.com/articles/s41587-023-01751-6",
  "summary": "A noncoding RNA map of 16 organs. miR-29c-3p tracks aging and returns to young levels in liver with young blood."
 },
 {
  "id": "debes-2023-elongation",
  "title": "Ageing-associated changes in transcriptional elongation influence longevity",
  "year": 2023,
  "venue": "Nature",
  "doi": "10.1038/s41586-023-05922-y",
  "url": "https://www.nature.com/articles/s41586-023-05922-y",
  "summary": "RNA polymerase speeds up with age in five species. Dietary restriction reverses most of this, and slowing polymerase extends lifespan."
 },
 {
  "id": "park-2023-platelet-factors",
  "title": "Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice",
  "year": 2023,
  "venue": "Nature Aging",
  "doi": "10.1038/s43587-023-00468-0",
  "url": "https://www.nature.com/articles/s43587-023-00468-0",
  "summary": "Klotho raises platelet factors in blood. One of them, PF4, improves cognition in young and old mice."
 },
 {
  "id": "iram-2022-young-csf",
  "title": "Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17",
  "year": 2022,
  "venue": "Nature",
  "doi": "10.1038/s41586-022-04722-0",
  "url": "https://www.nature.com/articles/s41586-022-04722-0",
  "summary": "Young cerebrospinal fluid improved memory in old mice. Fgf17 alone did too."
 },
 {
  "id": "demiguel-2021-exercise-plasma",
  "title": "Exercise plasma boosts memory and dampens brain inflammation via clusterin",
  "year": 2021,
  "venue": "Nature",
  "doi": "10.1038/s41586-021-04183-x",
  "url": "https://www.nature.com/articles/s41586-021-04183-x",
  "summary": "Plasma from running mice reduced brain inflammation in sedentary mice, through proteins including clusterin."
 },
 {
  "id": "yang-2021-covid-brain",
  "title": "Dysregulation of brain and choroid plexus cell types in severe COVID-19",
  "year": 2021,
  "venue": "Nature",
  "doi": "10.1038/s41586-021-03710-0",
  "url": "https://www.nature.com/articles/s41586-021-03710-0",
  "summary": "Brains from COVID-19 patients showed no molecular trace of virus but broad changes in barrier cells and microglia."
 },
 {
  "id": "marschallinger-2020-ldam",
  "title": "Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain",
  "year": 2020,
  "venue": "Nature Neuroscience",
  "doi": "10.1038/s41593-019-0566-1",
  "url": "https://www.nature.com/articles/s41593-019-0566-1",
  "summary": "Microglia fill with lipid droplets as brains age. These cells clear debris poorly and drive inflammation."
 },
 {
  "id": "tms-2020-tabula-muris-senis",
  "title": "A single-cell transcriptomic atlas characterizes ageing tissues in the mouse",
  "year": 2020,
  "venue": "Nature",
  "doi": "10.1038/s41586-020-2496-1",
  "url": "https://www.nature.com/articles/s41586-020-2496-1",
  "summary": "A single-cell atlas of aging across 23 mouse tissues and organs."
 },
 {
  "id": "riera-2017-smell",
  "title": "The Sense of Smell Impacts Metabolic Health and Obesity",
  "year": 2017,
  "venue": "Cell Metabolism",
  "doi": "10.1016/j.cmet.2017.06.015",
  "url": "https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30357-1",
  "summary": "Mice that lost smell neurons resisted diet-induced obesity. Losing smell after obesity reduced fat mass."
 },
 {
  "id": "hill-2016-causal-networks",
  "title": "Inferring causal molecular networks: empirical assessment through a community-based effort",
  "year": 2016,
  "venue": "Nature Methods",
  "doi": "10.1038/nmeth.3773",
  "url": "https://www.nature.com/articles/nmeth.3773",
  "summary": "A community challenge scored over 2,000 networks for causal links in cancer cell signaling."
 }
]