# Oliver Hahn

> I build AI-accelerated, closed-loop discovery systems for brain aging. Principal Investigator for Brain Aging at Calico Life Sciences. In middle school I read about DNA replication failures and got hooked on aging. Put young immune cells into an old brain and it ages them fast.

This site exists in three versions. Each is a complete site with the same content and its own llms.txt, papers.json and sitemap. Read any one of them.

- [A1](https://ohahn.com/a1/): a quiet page with a live cell, tabs for Science, Projects, Writing and People. Machine-readable: [llms.txt](https://ohahn.com/a1/llms.txt), [papers.json](https://ohahn.com/a1/papers.json).
- [B2](https://ohahn.com/b2/): a three-dimensional room you walk through. Machine-readable: [llms.txt](https://ohahn.com/b2/llms.txt).
- [C3](https://ohahn.com/c3/): a pixel-art town you walk through. Machine-readable: [llms.txt](https://ohahn.com/c3/llms.txt).

## CV

Full CV: [CV](https://ohahn.com/cv/). Summary:

- 2023 to present: Principal Investigator, Brain Aging, Calico Life Sciences. Leads computational, in vitro and in vivo discovery platforms for brain aging, including Perturb-seq screens of hundreds of gene targets and Cell Painting screens of 2,500+ compounds.
- 2018 to 2023: Postdoctoral Scholar, Stanford University, Wyss-Coray lab. Built the aging mouse brain atlas. 2020 to 2023: lead of the American Heart Association / Allen Brain Health RNA-seq core.
- 2015 to 2018: PhD, Genetics and Bioinformatics, Max Planck Institute for Biology of Ageing and University of Cologne, Partridge lab.
- 2012 to 2014: MSc, Molecular Biosciences and Systems Biology, Heidelberg University. 2009 to 2012: BSc, Molecular Biotechnology, Technical University of Munich.
- Built: Sentinel (2026, agent that predicts antigen targets for unknown T cell receptors; 2nd of 70 teams and People's Choice, Bio x AI Hackathon at Y Combinator), ANSWERBACK (2026), an in vivo immune cell replacement platform (2025), the aging mouse brain atlas (2023), Ember (2026).
- Skills: protein and genomic foundation models, agentic coding, single-cell multi-omics, causal network inference, in vivo CRISPR screens, Perturb-seq, lab automation, high-content and two-photon imaging.

Role: Principal Investigator for Brain Aging, Calico Life Sciences.
Profiles: [ORCID](https://orcid.org/0000-0001-9015-4545), [Google Scholar](https://scholar.google.com/citations?user=vpa2PmUAAAAJ), [GitHub](https://github.com/olihahn), [X](https://x.com/Oliver__Hahn), [LinkedIn](https://www.linkedin.com/in/oliver-hahn-ph-d-2363b3141/).