Oliver Hahn

I build AI-accelerated, closed-loop discovery systems for brain aging.

Built

2026

Sentinel

Agent that predicts antigen targets for unknown T cell receptors and designs validation experiments.

2nd of 70 teams and People's Choice, Bio x AI Hackathon at Y Combinator

2026

ANSWERBACK

Fixed-budget agent querying archived experiments to find which secreted factors change cells.

re:AGENT hackathon

2025

In vivo immune cell replacement platform

Swaps the aging brain's immune cells for young, gene-editable ones to find what drives aging.

2023

Aging mouse brain atlas

RNA atlas of 15 mouse brain regions across 7 ages, with a public browser.

2026

Ember

Android cigar journal whose home screen is a painted terrace you can lean into.

Skills

AI and computationProtein and genomic foundation models (ESM-2, Evo-2, Boltz-2, RFdiffusion, Borzoi), Agentic coding (Claude Code, Codex, Antigravity), Modal GPUs, Single-cell multi-omics, Causal network inference, ML for imaging, Python, R

Lab platformsIn vivo CRISPR screens, Perturb-seq, Lab automation, High-content imaging, Two-photon imaging in living brains, Immune cell replacement

Experience

2023 to present

Principal Investigator, Brain Aging

Calico Life Sciences

Leads brain aging research, building computational, in vitro and in vivo discovery platforms.

  • Perturb-seq screens of hundreds of gene targets, in vitro and in the aging brain.
  • Cell Painting screens of 2,500+ compounds, run with automation and AI.
  • Trusted tester for frontier lab AI tools and models.
2018 to 2023

Postdoctoral Scholar

Stanford University, Wyss-Coray lab

Built the aging mouse brain atlas and multiomic methods that measure aging across tissues.

2020 to 2023

Lead, American Heart Association / Allen Brain Health RNA-seq core

Stanford University

Ran bulk and single-cell RNA-seq projects for a consortium of ten Stanford labs.

2015 to 2018

PhD, Genetics and Bioinformatics

Max Planck Institute for Biology of Ageing and University of Cologne, Partridge lab

Diet, DNA methylation and aging in mice.

2012 to 2014

MSc, Molecular Biosciences and Systems Biology

Heidelberg University

2009 to 2012

BSc, Molecular Biotechnology

Technical University of Munich

Talks

2026

Panel, AI for preclinical neurosciencePsyMed Ventures Frontier Neuro (un)Conference, San Francisco

2026

Keystone Symposia, Immune Aging and Innate ImmunityBanff, Canada

2025

Society for NeuroscienceSan Diego

2025

Keystone Symposia, NeuroinflammationWhistler, Canada

2022

10x Genomics User SymposiumSan Francisco

2022

Gordon Research Conference, Systems AgingNewry, Maine

2020

Keystone Symposia, Intra- and Intercellular Mechanisms of AgingVancouver, Canada

2018

Cell Symposium, Aging and MetabolismSitges, Spain

2018

Healthy Ageing: From Molecules to OrganismsCambridge, UK

2017

Gordon Research Seminar, Biology of AgingLes Diablerets, Switzerland

Citations