Oliver Hahn

Science

Selected

  1. Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

    bioRxiv (preprint), senior author

    Young replacement microglia, the brain's immune cells, aged fast in old brains. Old ones looked young in young brains.

  2. Atlas of the aging mouse brain reveals white matter as vulnerable foci

    Cell, first author

    We profiled 15 mouse brain regions across 7 ages. Glial aging runs faster in white matter than cortex.

  3. CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method

    Nucleic Acids Research, first author

    CoolMPS sequencing reproduced standard Illumina results on single-nucleus RNA from young and old mouse hippocampus.

  4. Ageing hallmarks exhibit organ-specific temporal signatures

    Nature, co-first author

    Organs hit the same aging hallmarks on different schedules. Immune activation shows first in white fat.

  5. A nutritional memory effect counteracts the benefits of dietary restriction in old mice

    Nature Metabolism, first author

    In 800 mice, stopping dietary restriction at 24 months raised mortality fast. Starting it late helped only weakly.

  6. Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

    PLOS Genetics, first author

    Dietary restriction, rapamycin and dwarf genetics each add methylation inside gene bodies in mouse liver.

  7. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

    Genome Biology, co-first author

    Dietary restriction delayed age-related epigenetic changes in mouse liver and added methylation at lipid genes.

All

  1. Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

    bioRxiv (preprint), senior author

    Young replacement microglia, the brain's immune cells, aged fast in old brains. Old ones looked young in young brains.

  2. A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

    Nature Communications

    A microRNA atlas of 15 mouse brain regions. miR-155-5p rises with age in both sexes, driven by microglia.

  3. Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis

    Nature Neuroscience

    Replacing immune cells by transplant improved neurological deficits in a mouse model of multiple sclerosis.

  4. Atlas of the aging mouse brain reveals white matter as vulnerable foci

    Cell, first author

    We profiled 15 mouse brain regions across 7 ages. Glial aging runs faster in white matter than cortex.

  5. Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

    Nature Biotechnology

    A noncoding RNA map of 16 organs. miR-29c-3p tracks aging and returns to young levels in liver with young blood.

  6. Ageing-associated changes in transcriptional elongation influence longevity

    Nature

    RNA polymerase speeds up with age in five species. Dietary restriction reverses most of this, and slowing polymerase extends lifespan.

  7. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

    Nature Aging

    Klotho raises platelet factors in blood. One of them, PF4, improves cognition in young and old mice.

  8. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

    Nature

    Young cerebrospinal fluid improved memory in old mice. Fgf17 alone did too.

  9. Exercise plasma boosts memory and dampens brain inflammation via clusterin

    Nature

    Plasma from running mice reduced brain inflammation in sedentary mice, through proteins including clusterin.

  10. Dysregulation of brain and choroid plexus cell types in severe COVID-19

    Nature

    Brains from COVID-19 patients showed no molecular trace of virus but broad changes in barrier cells and microglia.

  11. CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method

    Nucleic Acids Research, first author

    CoolMPS sequencing reproduced standard Illumina results on single-nucleus RNA from young and old mouse hippocampus.

  12. Ageing hallmarks exhibit organ-specific temporal signatures

    Nature, co-first author

    Organs hit the same aging hallmarks on different schedules. Immune activation shows first in white fat.

  13. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

    Nature Neuroscience

    Microglia fill with lipid droplets as brains age. These cells clear debris poorly and drive inflammation.

  14. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

    Nature

    A single-cell atlas of aging across 23 mouse tissues and organs.

  15. A nutritional memory effect counteracts the benefits of dietary restriction in old mice

    Nature Metabolism, first author

    In 800 mice, stopping dietary restriction at 24 months raised mortality fast. Starting it late helped only weakly.

  16. Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

    PLOS Genetics, first author

    Dietary restriction, rapamycin and dwarf genetics each add methylation inside gene bodies in mouse liver.

  17. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

    Genome Biology, co-first author

    Dietary restriction delayed age-related epigenetic changes in mouse liver and added methylation at lipid genes.

  18. The Sense of Smell Impacts Metabolic Health and Obesity

    Cell Metabolism

    Mice that lost smell neurons resisted diet-induced obesity. Losing smell after obesity reduced fat mass.

  19. Inferring causal molecular networks: empirical assessment through a community-based effort

    Nature Methods

    A community challenge scored over 2,000 networks for causal links in cancer cell signaling.